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Cheap flights from Mexico City to Santiago from C$ 415

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 30/9. Fares are subject to change and may not be available on all flights or dates of travel.
MEX — SCL
22 Apr — 29 Apr1
1 adult

Cheap flight deals from Mexico City to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Mexico City (MEX) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 17 April 2025.

Round-trip from

C$ 708

One-way from

C$ 415

Popular in

February

Cheapest in

August

Average price

C$ 835
Copa Airlines
  • Copa Airlines
  • 22/5-7/6
  • 2 total stops
  • 37h 25m total
  • Mexico City to Santiago
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Avianca
  • Avianca
  • 30/9
  • 1 total stop
  • 12h 15m total
  • Mexico City to Santiago
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Highest demand for flights based on searches. 5% potential increase in price (C$ 73 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease (C$ 18 potential savings vs. average RT price).
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Average for round-trip flights in April 2025
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Find flight deals from Mexico City to Santiago

Cheapest flights from Mexico City to Santiago
Explore the most affordable flight options available from Mexico City to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 17 April 2025.

Thu 22/52:00 a.m.MEX - SCL
1 stop15h 24mCopa Airlines
Sun 8/64:11 a.m.SCL - MEX
1 stop19h 49mCopa Airlines
Deal found 17/4C$ 708
Tue 14/1011:20 p.m.MEX - SCL
1 stop12h 05mAvianca
Fri 24/107:10 a.m.SCL - MEX
1 stop13h 55mAvianca
Deal found 17/4C$ 810
Tue 14/108:20 p.m.MEX - SCL
Nonstop8h 20mLATAM Airlines
Fri 24/108:40 p.m.SCL - MEX
1 stop20h 10mLATAM Airlines
Deal found 17/4C$ 1,093
Fri 7/1110:05 a.m.MEX - SCL
Nonstop8h 10mAeromexico
Sun 16/1111:25 p.m.SCL - MEX
Nonstop8h 35mAeromexico
Deal found 17/4C$ 1,131
Tue 14/107:10 a.m.MEX - SCL
3 stops35h 25mMultiple Airlines
Thu 23/1012:55 a.m.SCL - MEX
2 stops25h 20mMultiple Airlines
Deal found 17/4C$ 2,426

Cheapflights Fare Finder

Customize your flight search to find flights from Mexico City to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 629,999 searches. Data last updated 17 April 2025.
Use the filters below to find and compare flights from Mexico City to Santiago that are best for you.

Fly from

Mexico City

Fly to

Santiago

Route

Depart

Return

Price

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Thu 22/5

2:00 a.m.-7:24 p.m.

1 stop15h 24m

Santiago Arturo Merino Benitez

Sat 7/6

2:24 a.m.-10:05 p.m.

1 stop21h 41m

C$ 708

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Tue 14/10

11:20 p.m.-2:25 p.m.

1 stop12h 05m

Santiago Arturo Merino Benitez

Fri 24/10

7:10 a.m.-6:05 p.m.

1 stop13h 55m

C$ 810

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Tue 14/10

8:20 p.m.-7:40 a.m.

Nonstop8h 20m

Santiago Arturo Merino Benitez

Fri 24/10

8:40 p.m.-1:50 p.m.

1 stop20h 10m

C$ 1,093

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Tue 14/10

7:10 a.m.-9:35 p.m.

3 stops35h 25m

Santiago Arturo Merino Benitez

Thu 23/10

12:55 a.m.-11:15 p.m.

2 stops25h 20m

C$ 2,426

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Tue 30/9

2:00 p.m.-5:15 a.m.

1 stop12h 15m

C$ 415

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Sat 3/5

3:00 a.m.-2:47 a.m.

1 stop21h 47m

C$ 776

Flights are sorted by cheapest round-trip flights first.

Deals found on 17/4

Best time to book a flight from Mexico City to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Mexico City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mexico City to Santiago

How far ahead should I book a flight from Mexico City to Santiago?

Use this chart to determine the optimal time to book a round-trip flight from Mexico City to Santiago. Price data was last updated on 11 April 2025.

The price you pay for your flight from Mexico City to Santiago may vary depending on when you book. For the best chance of a lower fare, look to book 83 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Mexico City to Santiago?

Currently, April is the cheapest month in which you can book a flight from Mexico City to Santiago (average of C$ 628). Flying from Mexico City to Santiago in December is currently the most expensive (average of C$ 903). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MEX to SCL?

Find hourly flight availability from Mexico City to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated 17 April 2025.

When flying from Mexico City to Santiago, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in Santiago by month

Plan your trip to Santiago by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Santiago ranges from 0.0 - 70.0 mm per month. June is typically the wettest month, when rainfall can reach 70.0 mm. January is typically the driest time to visit Santiago when rainfall is around 0.0 mm.

Temperature in Santiago by month

Plan your trip to Santiago by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Santiago, use this chart to help with planning. For those seeking warmer temperatures, January is the ideal time of year to visit, when temperatures reach an average of 21.0 C. Travellers hoping to avoid the cold should look outside of June, when temperatures are typically at their lowest (around 8.0 C).

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated 17 April 2025.
Copa Airlines
7.6
Good
1,409 reviews
Check prices

Crew

8.1

Entertainment

6.8

Overall

7.6

Comfort

7.4

Food

6.8

Boarding

7.8

Reviews

1 / 20
4.0
Okay

Anonymous,Mar 2025

PTY - JFK

There was no chance for me to choose a seat even if I were willing to pay extra for it when I was doing the check-in on line. My seats were the last row on the plane and they didn't have enough food to give me. I had to eat what was left after everybody else had their choice of food. This is unacceptable. Everyone should have a choice. I paid money just like everybody else. Never had this happened on any other airlines even if my seats were last row on the plane.
Copa Airlines
7.6
Good
1,409 reviews
Copa Airlines
7.6
Good
1,409 reviews
Check prices

Crew

8.1

Entertainment

6.8

Overall

7.6

Comfort

7.4

Food

6.8

Boarding

7.8

Reviews

1 / 20
4.0
Okay

Anonymous,Mar 2025

PTY - JFK

There was no chance for me to choose a seat even if I were willing to pay extra for it when I was doing the check-in on line. My seats were the last row on the plane and they didn't have enough food to give me. I had to eat what was left after everybody else had their choice of food. This is unacceptable. Everyone should have a choice. I paid money just like everybody else. Never had this happened on any other airlines even if my seats were last row on the plane.
LATAM Airlines
7.5
Good
1,761 reviews
Copa Airlines
7.6
Good
1,409 reviews
Check prices

Crew

8.1

Entertainment

6.8

Overall

7.6

Comfort

7.4

Food

6.8

Boarding

7.8

Reviews

1 / 20
4.0
Okay

Anonymous,Mar 2025

PTY - JFK

There was no chance for me to choose a seat even if I were willing to pay extra for it when I was doing the check-in on line. My seats were the last row on the plane and they didn't have enough food to give me. I had to eat what was left after everybody else had their choice of food. This is unacceptable. Everyone should have a choice. I paid money just like everybody else. Never had this happened on any other airlines even if my seats were last row on the plane.
Avianca
6.7
Okay
2,315 reviews
Copa Airlines
7.6
Good
1,409 reviews
Check prices

Crew

8.1

Entertainment

6.8

Overall

7.6

Comfort

7.4

Food

6.8

Boarding

7.8

Reviews

1 / 20
4.0
Okay

Anonymous,Mar 2025

PTY - JFK

There was no chance for me to choose a seat even if I were willing to pay extra for it when I was doing the check-in on line. My seats were the last row on the plane and they didn't have enough food to give me. I had to eat what was left after everybody else had their choice of food. This is unacceptable. Everyone should have a choice. I paid money just like everybody else. Never had this happened on any other airlines even if my seats were last row on the plane.

Related info for your journey

Find useful and relevant information for your journey from Mexico City to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Mexico City to Santiago flight route?

    This flight path from Mexico City Benito Juarez to Santiago Arturo Merino Benitez was viewed by 1 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • What are the cheapest airlines flying from Mexico City to Santiago round-trip?

    Flying on Copa Airlines is currently your cheapest option to Santiago, with prices starting at C$ 708. Additional round-trip tickets that might be worth considering are offered by Avianca and LATAM Airlines, with the lowest prices starting at C$ 810 and C$ 1,093, respectively. Users have found that Copa Airlines is 18% cheaper than the other options available to this destination.

  • What are the most reliable airlines from Mexico City to Santiago?

    Consider WestJet (86%), Aeromexico (86%) or LATAM Airlines (85%) when booking your flight. These represent the most reliable airlines when flying from Mexico City to Santiago.

  • Can I find deals for flights from Mexico City to Santiago that include hotel bookings?

    Yes. In addition to deals on Mexico City to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mexico City to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mexico City to Santiago.

  • Can I find deals for business class flights from Mexico City to Santiago?

    Yes. Cheapflights offers flight deals from Mexico City to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mexico City to Santiago?

    Currently, April is the cheapest month in which you can book a flight from Mexico City to Santiago (average of C$ 628). Flying from Mexico City to Santiago in December is currently the most expensive (average of C$ 903). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Why should you use Cheapflights to find cheap flight tickets from Mexico City to Santiago?

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Can Cheapflights find flights from Mexico City to Santiago with no change fees?

Cheapflights does show flights with no change fees to all users. To see these options for flights from Mexico City to Santiago, users can toggle the no change fees filter when performing a flight search.

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Yes, and it’s super simple to set up. Click the bell icon next to the flight deals above and provide a valid email address to enable Price Alerts. That’s it!

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