What are the cheapest airlines to fly from Buffalo to South Carolina one-way?

The cheapest airlines for a one-way flight from Buffalo to South Carolina are Southwest (C$ 136), United Airlines (C$ 192), and Delta (C$ 206).

What are the most popular routes from Buffalo to South Carolina?

When deciding which route to take from Buffalo to South Carolina consider Buffalo - Charlotte Douglas, Buffalo - Charleston or Buffalo - Savannah/Hilton Head as they are the most popular.

What are the most popular airlines that fly from Buffalo to South Carolina?

The most popular airlines flying from Buffalo to South Carolina are American Airlines, Delta and United Airlines. Something to consider prior to booking your flight.

How far in advance should I book a flight from Buffalo to South Carolina?

To save on the cost of your flight from Buffalo to South Carolina, book at least 29 days before your planned departure. Booking around this time can save you about 73% on the cost of this flight compared to booking a flight leaving this week. We have found prices from C$ 637 if you need a flight within two weeks. For flights within the next 72 hours, you can find tickets from as low as C$ 709.

What is the cheapest month to fly from Buffalo to South Carolina?

Flights from Buffalo to South Carolina lean towards being more expensive in April. Prices are generally better when you fly from Buffalo to South Carolina in September, with the cheapest ticket starting at C$ 277.

What airport do you fly from for flights from Buffalo to South Carolina?

For a flight from Buffalo to South Carolina, you will be flying from Buffalo. Buffalo (BUF) is just 13.4 km from the centre of the city.

Can I find deals for flights from Buffalo to South Carolina that include hotel bookings?

Yes. In addition to deals on Buffalo to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Buffalo to South Carolina?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Buffalo to South Carolina.

Can I find deals for business class flights from Buffalo to South Carolina?

Yes. Cheapflights offers flight deals from Buffalo to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

C$ 136+ Flights from Buffalo to South Carolina

Cheap flight deals from Buffalo to South Carolina

Round-trip from	C$ 263
One-way from	C$ 136
Popular in	April
Cheapest in	September
Average price	C$ 580

Southwest
28/4-6/5
2 total stops
8h 40m total
Buffalo to South Carolina

Search Deals

Southwest
20/4
1 total stop
4h 45m total
Buffalo to South Carolina

Search Deals

Highest demand for flights based on searches. 8% potential increase in price (C$ 66 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 1% potential price decrease (C$ 10 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in March 2025

Search Deals

Find flight deals from Buffalo to South Carolina

Cheapest flights from Buffalo to South Carolina
Explore the most affordable flight options available from Buffalo to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 28 March 2025.

Mon 28/43:35 p.m.BUF - CLT

1 stop5h 20mSouthwest

Thu 1/57:30 a.m.CLT - BUF

1 stop6h 10mSouthwest

Deal found 27/3C$ 270

Tue 24/66:30 a.m.BUF - CLT

1 stop5h 28mDelta

Mon 30/67:35 p.m.CLT - BUF

1 stop3h 35mDelta

Deal found 27/3C$ 282

Wed 30/41:50 p.m.BUF - SAV

1 stop7h 10mSouthwest

Tue 6/56:00 p.m.SAV - BUF

1 stop4h 35mSouthwest

Deal found 27/3C$ 284

Sun 6/45:32 p.m.BUF - CLT

1 stop14h 11mFrontier

Thu 10/411:20 a.m.CLT - BUF

1 stop23h 08mFrontier

Deal found 27/3C$ 284

Wed 30/46:00 a.m.BUF - SAV

2 stops9h 03mUnited Airlines

Tue 6/511:34 a.m.SAV - BUF

1 stop5h 21mUnited Airlines

Deal found 27/3C$ 292

Tue 24/612:14 p.m.BUF - CLT

1 stop5h 10mAmerican Airlines

Sun 29/64:45 p.m.CLT - BUF

Nonstop1h 47mAmerican Airlines

Deal found 27/3C$ 317

Sat 24/56:55 p.m.BUF - CHS

1 stop4h 49mDelta

Tue 27/56:24 p.m.CHS - BUF

1 stop5h 31mDelta

Deal found 27/3C$ 317

Wed 12/1112:09 p.m.BUF - SAV

1 stop5h 21mDelta

Mon 17/116:30 p.m.SAV - BUF

1 stop5h 29mDelta

Deal found 27/3C$ 327

Thu 1/57:55 p.m.BUF - CLT

1 stop4h 03mUnited Airlines

Sat 3/56:00 a.m.CLT - BUF

2 stops8h 47mUnited Airlines

Deal found 27/3C$ 352

Wed 14/57:11 p.m.BUF - CHS

1 stop5h 04mAmerican Airlines

Mon 19/58:43 p.m.CHS - BUF

1 stop3h 31mAmerican Airlines

Deal found 27/3C$ 356

Sat 16/86:35 a.m.BUF - CHS

2 stops10h 05mSouthwest

Mon 18/85:30 a.m.CHS - BUF

1 stop6h 35mSouthwest

Deal found 27/3C$ 396

Wed 14/56:05 a.m.BUF - MYR

1 stop5h 34mDelta

Wed 21/51:08 p.m.MYR - BUF

1 stop4h 22mDelta

Deal found 26/3C$ 410

Best flights from Buffalo to South Carolina
Discover carefully curated flight deals from Buffalo to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated 28 March 2025.

Mon 28/43:35 p.m.BUF - CLT

1 stop5h 20mSouthwest

Tue 6/57:00 a.m.CLT - BUF

1 stop3h 20mSouthwest

Deal found 26/3C$ 263

Fri 25/412:50 p.m.BUF - CLT

1 stop5h 30mDelta

Mon 28/46:04 a.m.CLT - BUF

1 stop3h 41mDelta

Deal found 26/3C$ 282

Wed 30/46:00 a.m.BUF - SAV

2 stops9h 03mUnited Airlines

Tue 6/511:34 a.m.SAV - BUF

1 stop5h 21mUnited Airlines

Deal found 27/3C$ 292

Wed 2/47:00 p.m.BUF - CLT

1 stop15h 00mFrontier

Tue 8/49:38 p.m.CLT - BUF

1 stop12h 46mFrontier

Deal found 26/3C$ 299

Wed 14/57:11 p.m.BUF - CHS

1 stop5h 04mAmerican Airlines

Mon 19/58:43 p.m.CHS - BUF

1 stop3h 31mAmerican Airlines

Deal found 27/3C$ 356

Mon 7/411:29 a.m.BUF - CHS

1 stop8h 48mJetBlue

Tue 15/45:24 p.m.CHS - BUF

1 stop4h 33mJetBlue

Deal found 27/3C$ 522

Wed 30/41:50 p.m.BUF - SAV

1 stop7h 10mSouthwest

Tue 6/56:00 p.m.SAV - BUF

1 stop4h 35mSouthwest

Deal found 27/3C$ 284

Wed 30/46:00 a.m.BUF - CLT

2 stops8h 07mUnited Airlines

Wed 7/510:41 a.m.CLT - BUF

2 stops8h 10mUnited Airlines

Deal found 26/3C$ 296

Sat 24/56:55 p.m.BUF - CHS

1 stop4h 49mDelta

Tue 27/56:24 p.m.CHS - BUF

1 stop5h 31mDelta

Deal found 27/3C$ 317

Fri 16/57:11 p.m.BUF - CLT

Nonstop1h 56mAmerican Airlines

Mon 2/610:28 p.m.CLT - BUF

Nonstop1h 46mAmerican Airlines

Deal found 27/3C$ 400

Sat 16/86:35 a.m.BUF - CHS

2 stops10h 05mSouthwest

Mon 18/85:30 a.m.CHS - BUF

1 stop6h 35mSouthwest

Deal found 27/3C$ 396

Wed 14/56:00 a.m.BUF - MYR

1 stop6h 29mDelta

Sat 17/56:00 a.m.MYR - BUF

1 stop5h 13mDelta

Deal found 27/3C$ 410

Last-minute flights from Buffalo to South Carolina
Discover last-minute flight deals from Buffalo to South Carolina. Data last updated 28 March 2025 and is based on user searches.

Tue 1/43:19 p.m.BUF - CLT

1 stop6h 25mUnited Airlines

Tue 8/42:48 p.m.CLT - BUF

2 stops8h 56mUnited Airlines

Deal found 27/3C$ 686

Wed 2/47:00 a.m.BUF - SAV

1 stop14h 16mDelta

Wed 9/47:00 a.m.SAV - BUF

1 stop4h 09mDelta

Deal found 27/3C$ 766

Wed 2/45:50 a.m.BUF - SAV

1 stop4h 55mSouthwest

Wed 9/411:25 a.m.SAV - BUF

2 stops7h 30mSouthwest

Deal found 27/3C$ 795

Thu 3/411:59 a.m.BUF - CLT

Nonstop1h 54mAmerican Airlines

Sat 5/47:26 a.m.CLT - BUF

Nonstop1h 39mAmerican Airlines

Deal found 26/3C$ 616

Fri 4/43:19 p.m.BUF - CHS

2 stops8h 40mUnited Airlines

Mon 7/46:00 a.m.CHS - BUF

1 stop3h 40mUnited Airlines

Deal found 27/3C$ 806

Sun 6/45:32 p.m.BUF - CLT

1 stop14h 11mFrontier

Thu 10/411:20 a.m.CLT - BUF

1 stop23h 08mFrontier

Deal found 27/3C$ 284

Sun 6/47:00 a.m.BUF - CHS

1 stop5h 15mDelta

Fri 18/45:35 a.m.CHS - BUF

1 stop5h 25mDelta

Deal found 27/3C$ 667

Sun 6/43:00 p.m.BUF - CLT

2 stops8h 35mSouthwest

Thu 10/47:30 a.m.CLT - BUF

1 stop6h 10mSouthwest

Deal found 27/3C$ 779

Mon 7/411:29 a.m.BUF - CHS

1 stop8h 48mJetBlue

Tue 15/45:24 p.m.CHS - BUF

1 stop4h 33mJetBlue

Deal found 27/3C$ 522

Tue 15/42:55 p.m.BUF - CHS

1 stop5h 20mSouthwest

Tue 22/46:30 p.m.CHS - BUF

1 stop4h 05mSouthwest

Deal found 27/3C$ 429

Wed 16/411:47 a.m.BUF - CLT

Nonstop1h 57mAmerican Airlines

Wed 23/47:26 a.m.CLT - BUF

Nonstop1h 39mAmerican Airlines

Deal found 26/3C$ 429

Thu 17/47:45 p.m.BUF - CLT

1 stop4h 14mUnited Airlines

Wed 23/410:43 a.m.CLT - BUF

1 stop6h 12mUnited Airlines

Deal found 27/3C$ 410

One-way flights from Buffalo to South Carolina
Search for one-way flight options from Buffalo to South Carolina. Find affordable one-way fares based on user searches. Data last updated 28 March 2025.

Sun 20/46:25 a.m.BUF - CLT

1 stop4h 45mSouthwest

Deal found 26/3C$ 136

Thu 17/410:54 a.m.BUF - CLT

1 stop6h 58mUnited Airlines

Deal found 27/3C$ 192

Wed 2/710:38 a.m.BUF - MYR

1 stop6h 05mDelta

Deal found 27/3C$ 206

Sun 27/75:55 a.m.BUF - CHS

1 stop3h 50mSouthwest

Deal found 27/3C$ 214

Sat 26/45:10 p.m.BUF - MYR

1 stop3h 35mSouthwest

Deal found 27/3C$ 234

Sun 11/512:01 p.m.BUF - MYR

1 stop5h 38mAmerican Airlines

Deal found 26/3C$ 249

Tue 8/46:00 a.m.BUF - CHS

1 stop5h 21mDelta

Deal found 27/3C$ 274

Wed 16/47:00 a.m.BUF - SAV

1 stop8h 18mUnited Airlines

Deal found 27/3C$ 316

Mon 7/47:05 a.m.BUF - CHS

1 stop4h 40mJetBlue

Deal found 27/3C$ 327

Sun 13/47:45 p.m.BUF - CHS

1 stop4h 14mUnited Airlines

Deal found 27/3C$ 332

Thu 3/412:17 p.m.BUF - SAV

1 stop6h 54mDelta

Deal found 27/3C$ 334

Sun 11/56:00 a.m.BUF - MYR

2 stops8h 27mUnited Airlines

Deal found 26/3C$ 380

Cheapflights Fare Finder

Use the filters below to find and compare flights from Buffalo to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

BuffaloCharlotte

BUF - CLT

BUFCLT

Buffalo

Mon 28/4

3:35 p.m.-8:55 p.m.

1 stop5h 20m

Charlotte Douglas

Thu 1/5

7:30 a.m.-1:40 p.m.

1 stop6h 10m

C$ 270

BuffaloCharlotte

BUF - CLT

BUFCLT

Buffalo

Tue 24/6

6:30 a.m.-11:58 a.m.

1 stop5h 28m

Charlotte Douglas

Mon 30/6

7:35 p.m.-11:10 p.m.

1 stop3h 35m

C$ 282

BuffaloCharlotte

BUF - CLT

BUFCLT

Buffalo

Sun 6/4

5:32 p.m.-7:43 a.m.

1 stop14h 11m

Charlotte Douglas

Thu 10/4

11:20 a.m.-10:28 a.m.

1 stop23h 08m

C$ 284

BuffaloSavannah

BUF - SAV

BUFSAV

Buffalo

Wed 30/4

1:50 p.m.-9:00 p.m.

1 stop7h 10m

Savannah/Hilton Head

Tue 6/5

6:00 p.m.-10:35 p.m.

1 stop4h 35m

C$ 284

BuffaloSavannah

BUF - SAV

BUFSAV

Buffalo

Wed 30/4

6:00 a.m.-3:03 p.m.

2 stops9h 03m

Savannah/Hilton Head

Tue 6/5

11:34 a.m.-4:55 p.m.

1 stop5h 21m

C$ 292

BuffaloCharlotte

BUF - CLT

BUFCLT

Buffalo

Tue 24/6

12:14 p.m.-5:24 p.m.

1 stop5h 10m

Charlotte Douglas

Sun 29/6

4:45 p.m.-6:32 p.m.

Nonstop1h 47m

C$ 317

BuffaloCharleston

BUF - CHS

BUFCHS

Buffalo

Sat 24/5

6:55 p.m.-11:44 p.m.

1 stop4h 49m

Charleston

Tue 27/5

6:24 p.m.-11:55 p.m.

1 stop5h 31m

C$ 317

BuffaloCharlotte

BUF - CLT

BUFCLT

Buffalo

Thu 1/5

7:55 p.m.-11:58 p.m.

1 stop4h 03m

Charlotte Douglas

Sat 3/5

6:00 a.m.-2:47 p.m.

2 stops8h 47m

C$ 352

BuffaloCharleston

BUF - CHS

BUFCHS

Buffalo

Wed 14/5

7:11 p.m.-12:15 a.m.

1 stop5h 04m

Charleston

Mon 19/5

8:43 p.m.-12:14 a.m.

1 stop3h 31m

C$ 356

BuffaloCharleston

BUF - CHS

BUFCHS

Buffalo

Sat 16/8

6:35 a.m.-4:40 p.m.

2 stops10h 05m

Charleston

Mon 18/8

5:30 a.m.-12:05 p.m.

1 stop6h 35m

C$ 396

Flights are sorted by cheapest round-trip flights first.

Deals found on 26/3

Showing 1-10 of 31 results

Best time to book a flight from Buffalo to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Buffalo with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Buffalo to South Carolina

What is the cheapest month to book a flight from Buffalo to South Carolina?

Currently, September is the cheapest month in which you can book a flight from Buffalo to South Carolina (average of C$ 407). Flying from Buffalo to South Carolina in May is currently the most expensive (average of C$ 542). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from BUF to SC?

When flying from Buffalo to South Carolina, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in South Carolina by month

In terms of precipitation, rainfall in South Carolina ranges from 76.0 - 165.0 mm per month. July is typically the wettest month, when rainfall can reach 165.0 mm. November is typically the driest time to visit South Carolina when rainfall is around 76.0 mm.

Temperature in South Carolina by month

If weather is an important factor for your trip to South Carolina, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 26.0 C. Travellers hoping to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 7.0 C).

Reviews of airlines servicing South Carolina

Peruse reviews from past customers who have flown with Southwest, Delta and United Airlines from Buffalo to South Carolina to help guide your decision. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Southwest

8.1

Very good

4,274 reviews

Check prices

Reviews

1 / 20

8.0

Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.

Southwest

8.1

Very good

4,274 reviews

Southwest

8.1

Very good

4,274 reviews

Check prices

Reviews

1 / 20

8.0

Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.

Delta

8.0

Very good

7,897 reviews

Southwest

8.1

Very good

4,274 reviews

Check prices

Reviews

1 / 20

8.0

Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.

United Airlines

7.4

Good

8,603 reviews

Southwest

8.1

Very good

4,274 reviews

Check prices

Reviews

1 / 20

8.0

Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.

JetBlue

7.3

Good

2,923 reviews

Southwest

8.1

Very good

4,274 reviews

Check prices

Reviews

1 / 20

8.0

Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.

American Airlines

7.2

Good

10,000 reviews

Southwest

8.1

Very good

4,274 reviews

Check prices

Reviews

1 / 20

8.0

Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.

Related info for your journey

What airport do you fly from for flights from Buffalo to South Carolina?
For a flight from Buffalo to South Carolina, you will be flying from Buffalo. Buffalo (BUF) is just 13.4 km from the centre of the city.
What are the cheapest airlines to fly from Buffalo to South Carolina one-way?
The cheapest airlines for a one-way flight from Buffalo to South Carolina are Southwest (C$ 136), United Airlines (C$ 192), and Delta (C$ 206).
What are the most popular routes from Buffalo to South Carolina?
When deciding which route to take from Buffalo to South Carolina consider Buffalo - Charlotte Douglas, Buffalo - Charleston or Buffalo - Savannah/Hilton Head as they are the most popular.
Can I find deals for flights from Buffalo to South Carolina that include hotel bookings?
Yes. In addition to deals on Buffalo to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Buffalo to South Carolina?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Buffalo to South Carolina.
Can I find deals for business class flights from Buffalo to South Carolina?
Yes. Cheapflights offers flight deals from Buffalo to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Buffalo to South Carolina?
Currently, September is the cheapest month in which you can book a flight from Buffalo to South Carolina (average of C$ 407). Flying from Buffalo to South Carolina in May is currently the most expensive (average of C$ 542). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Complete your trip

South Carolina car rentals

Charleston Airport car rentals

Myrtle Beach Intl Airport car rentals

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Direct flights to United States

Top 4 airlines flying from Buffalo to South Carolina

Airline	Cheapest	Average	Flexibility	On-time
American Airlines	CheapestC$ 252	AverageC$ 436	FlexibilityNo cancel fee	On-time71%	Search American Airlines flights
Delta	CheapestC$ 264	AverageC$ 388	FlexibilityNo cancel fee	On-timeN/A	Search Delta flights
Southwest	CheapestC$ 359	AverageC$ 563	FlexibilityNo cancel fee	On-time63%	Search Southwest flights
United Airlines	CheapestC$ 367	AverageC$ 701	FlexibilityNo cancel fee	On-time69%	Search United Airlines flights

Fly with Cheapflights

How does Cheapflights help users find flights from Buffalo to South Carolina?

Cheapflights goes through 900+ travel sites to look for the best flight deals for flights from Buffalo to South Carolina. Too many options? Cheapflights also provides filters for things like airlines, price ranges, and number of stops to help you make a decision easily.

Why should you use Cheapflights to find cheap flight tickets from Buffalo to South Carolina?

Cheapflights taps into our reliable network of hundreds of airlines and travel agencies to find the best deals for flights from Buffalo to South Carolina for you. Better yet — we are completely free to use.

Can Cheapflights find flights from Buffalo to South Carolina with no change fees?

Certainly. Search results for flights to South Carolina from Buffalo shown to you on Cheapflights can be narrowed down with different useful search filters, which includes flexible booking options.

Can Cheapflights notify me if prices for flights from Buffalo to South Carolina become cheaper?

Yes, Cheapflights offers price alerts on Buffalo to South Carolina flights so you can book your travel at the perfect time. Price Alerts can be enabled by clicking the bell icon next to the flight deals above and providing your email address where you want to receive the alerts.

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Cheap flights from Buffalo to South Carolina from C$ 136

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 20/4. Fares are subject to change and may not be available on all flights or dates of travel.

Cheap flight deals from Buffalo to South Carolina

Keep the following information in mind while searching for Buffalo to South Carolina flight deals. Data was last updated 28 March 2025.

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from Buffalo to South Carolina

Cheapest flights from Buffalo to South CarolinaExplore the most affordable flight options available from Buffalo to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 28 March 2025.

Explore the most affordable flight options available from Buffalo to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 28 March 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Buffalo to South Carolina that are best for you.

Best time to book a flight from Buffalo to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Buffalo with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Buffalo to South Carolina

What is the cheapest month to book a flight from Buffalo to South Carolina?

What is the cheapest time of day to fly from BUF to SC?

Find hourly flight availability from Buffalo to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated 28 March 2025.

Rainfall in South Carolina by month

Plan your trip to South Carolina by taking into account the average rainfall totals by month.

Temperature in South Carolina by month

Plan your trip to South Carolina by taking into account the average temperature totals by month.

Reviews of airlines servicing South Carolina

Peruse reviews from past customers who have flown with Southwest, Delta and United Airlines from Buffalo to South Carolina to help guide your decision. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Buffalo to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What airport do you fly from for flights from Buffalo to South Carolina?

What are the cheapest airlines to fly from Buffalo to South Carolina one-way?

What are the most popular routes from Buffalo to South Carolina?

Can I find deals for flights from Buffalo to South Carolina that include hotel bookings?

How can I find direct flights from Buffalo to South Carolina?

Can I find deals for business class flights from Buffalo to South Carolina?

What is the cheapest month to book a flight from Buffalo to South Carolina?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Buffalo to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.

Top 4 airlines flying from Buffalo to South Carolina

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How does Cheapflights help users find flights from Buffalo to South Carolina?

Why should you use Cheapflights to find cheap flight tickets from Buffalo to South Carolina?

Can Cheapflights find flights from Buffalo to South Carolina with no change fees?

Can Cheapflights notify me if prices for flights from Buffalo to South Carolina become cheaper?

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Cheapest flights from Buffalo to South Carolina
Explore the most affordable flight options available from Buffalo to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 28 March 2025.